研究队伍
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姓  名:
高 福(George F Gao)
学  科:
比较与进化免疫学
联系电话:
010-64807688
电子邮件:
gaof@im.ac.cn,gaogf@biols.ac.cn
通讯地址:
北京市朝阳区北辰西路1号院5号 100101
更多信息:
  
简历:
    博士,研究员,博士生导师,中国科学院院士。现任中科院北京生科院副院长、中科院微生物所病原微生物与免疫学重点实验室主任、中国疾病预防控制中心副主任,英国牛津大学客座教授,国际抗病毒联盟(ICAV)国际执委会委员。2004年入选中科院“百人计划”,2005年获“国家杰出青年基金”资助,2005、2011年连续两次担任国家973项目“病毒跨种间传播机制”的首席科学家,是国家基金委“病原微生物与宿主互作”创新研究群体带头人。在多个国际杂志编委会任职。曾获国家科技进步奖二等奖,中华医学科技奖一等奖,中华预防医学会科学技术奖一等奖,北京市科学技术奖一等奖,谈家桢生命科学创新奖,中国青年科技奖等。2012年获得发展中国家科学院(TWAS)基础医学奖。2013年获年度科技盛典—中央电视台科技创新人物。
研究领域:
    利用结构生物学技术等手段研究细胞免疫识别的分子基础与病原微生物跨种间传播的分子机制,以及免疫相关分子的起源、结构基础与进化规律,进而阐明机体免疫系统和病原的相互进化关系。
代表论著:
  1. Shi Y., Zhang W., Wang F., Qi J., Wu Y., Song H., Gao F., Bi Y., Zhang Y., Fan Z., Qin C., Sun H., Liu J., Haywood J., Liu W., Gong W., Wang D., Shu Y., Wang Y., Yan J., Gao*, G. F., Structures and receptor binding of hemagglutinins from human-infecting H7N9 influenza viruses. Science, 2013, 342(6155):243-247.
  2. Lu G., Hu Y., Wang Q., Qi J., Gao F., Li Y., Zhang Y., Zhang W., Yuan Y., Bao J., Zhang B., Shi Y., Yan J., Gao*, G. F.,  Molecular basis of binding between novel human coronavirus MERS-CoV and its receptor CD26. Nature, 2013, 500(7461): 227-231.
  3. Zhang W., Shi Y., Lu X., Shu Y., Qi J., Gao*, G. F., An airborne transmissible avian influenza H5 hemagglutinin seen at the atomic level. Science. 2013;340(6139):1463-1467.
  4. Liu D., Shi W., Shi Y., Wang D., Xiao H., Li W., Bi Y., Wu Y., Li X., Yan J., Liu W., Zhao G., Yang W., Wang Y., Ma J., Shu Y.*, Lei* F., Gao*, G. F., Origin and diversity of novel avian influenza A H7N9 viruses causing human infection: phylogenetic, structural, and coalescent analyses. The Lancet. 2013; 381(9881): 1926-1932.
  5. Zhang X., Lu G., Qi J., Li Y., He Y., Xu X., Shi J., Zhang C. W., Yan J., Gao*, G. F., Structure of measles virus hemagglutinin bound to its epithelial receptor nectin-4. Nature Structural & Molecular Biology. 2013;20(1):67-72.
  6. Vavricka C. J., Liu Y., Kiyota H., Sriwilaijaroen N., Qi J., Tanaka K., Wu Y., Li Q., Li Y., Yan J., Suzuki Y., Gao*, G. F., Influenza neuraminidase operates via a nucleophilic mechanism and can be targeted by covalent inhibitors. Nature Communications. 2013;4:1491.
  7. Wu Y., Bi Y., Vavricka C. J., Sun X., Zhang Y., Gao F., Zhao M., Xiao H., Qin C., He J., Liu W., Yan J., Qi J., Gao*, G. F.,Characterization of two distinct neuraminidases from avian-origin human-infecting H7N9 influenza viruses. Cell Research, 2013;23(12):1347-1355.
  8. Sun X., Shi Y., Lu X., He J., Gao F., Yan J., Qi J., Gao*, G. F., Bat-derived influenza hemagglutinin H17 does not bind canonical avian or human receptors and most likely uses a unique entry mechanism. Cell Reports, 2013, 3(3): 769-778.
  9. Zhang, S., Lu, G., Qi, J., Li, Y., Zhang, Z., Zhang B., Yan, J. and Gao*, G. F., 2013, Competition of cell adhesion and immune recognition: insights into the interaction between CRTAM and Nectin-like 2, Structure, 21 (8): 1430-1439.
  10. Zhang, J., Chen Y., Qi, J., Gao, F., Liu, Y., Liu, J., Zhou, X., Kaufman, J., Xia*, C., Gao*, G. F., Narrow groove and restricted anchors of MHC class I molecule BF2*0401 plus peptide transporter restriction can explain disease susceptibility of B4 chickens. The Journal of Immunology, 2012;189(9):4478-4487.
  11. Li Q., Sun X., Li Z., Liu Y., Vavricka C. J., Qi J., Gao*, G. F., Structural and functional characterization of neuraminidase-like molecule N10 derived from bat influenza A virus. Proceedings of the National Academy of Sciences of the United States of America. 2012;109(46):18897-18902.
  12. Liu, J., Qian, X., Chen, Z., Xu, X., Gao, F., Zhang, S., Zhang, R., Qi, J., Yan*, J. and Gao*, G. F., 2012, Crystal structure of cell adhesion molecule nectin-2/CD112 and its binding to immune receptor DNAM-1/CD226. The Journal of Immunology, 188 (11): 5511-5520.
  13. Vavricka C. J., Li Q., Wu Y., Qi J., Wang M., Liu Y., Gao F., Liu J., Feng E., He J., Wang J., Liu H., Jiang H., Gao*, G. F., Structural and functional analysis of laninamivir and its octanoate prodrug reveals group specific mechanisms for influenza NA inhibition. PLoS Pathogens. 2011;7(10):e1002249.
  14. Zhang N., Yan J., Lu G., Guo Z., Fan Z., Wang J., Shi Y., Qi J., Gao* G. F. Binding of herpes simplex virus glycoprotein D to nectin-1 exploits host cell adhesion. Nature Communications. 2011;2:577.
  15. Li Q., Qi J., Zhang W., Vavricka C. J., Shi Y., Wei J., Feng E., Shen J., Chen J., Liu D., He J., Yan J., Liu H., Jiang H., Teng M., Li X., Gao* G. F. The 2009 pandemic H1N1 neuraminidase N1 lacks the 150-cavity in its active site. Nature Structural & Molecular Biology. 2010;17(10):1266-1268.
  16. Liu J.*, Xiao H., Lei F., Zhu Q., Qin K., Zhang X. W., Zhang X. L., Zhao D., Wang G.,Feng Y., Ma J., Liu W., Wang J., Gao* G. F., Highly pathogenic H5N1 influenza virus infection in migratory birds. Science, 2005, 309 (5738): 1206.
  17. Meng, S. D., Gao, T., Gao, G. F. and Tien*, P., 2001, HBV-specific peptide associated with heat-shock protein gp96. The Lancet, 357 (9255): 528-529.
  18. Wyer*, J. R., Willcox*, B. E., Gao*, G. F., Gerth, U. C., Davis, S. J., Bell, J. I., van der Merwe, P. A. andJakobsen, B. K., 1999, T cell receptor and coreceptor CD8 αα bind peptide-MHC independently and with distinct kinetics. Immunity, 10 (2): 219-225. (*Shared first authors)
  19. Willcox*, B. E., Gao*, G. F., Wyer*, J. R., Ladbury, J. E., Bell, J. I., Jakobsen, B. K. and van der Merwe, P. A., 1999, TCR binding to peptide-MHC stabilizes a flexible recognition interface. Immunity, 10 (3): 357-365. (*Shared first authors)
  20. Gao G. F., Tormo J., Gerth U. C., Wyer J. R., McMichael A. J., Stuart D. I., Bell J. I., Jones E. Y., Jakobsen B. K., Crystal structure of the complex between human CD8αα and HLA-A2. Nature, 1997, 387: 630-634. (With front cover illustration and short title in the cover page: CD8 comes to grips with MHC).
研究组成员:

工作人员 
戴连攀 博士 副研究员 
宋  豪 博士 助理研究员


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