副研究员
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姓  名:
宋豪
学  科:
生物化学与分子生物学
联系电话:
电子邮件:
songh@biols.ac.cn
通讯地址:
北京市朝阳区北辰西路1号院5号 100101
更多信息:
  
简历:

  博士,副研究员,国家自然科学基金优秀青年科学基金获得者,中国科学院青年创新促进会优秀会员,中国微生物学会病毒学专业委员会青年委员会委员。2016年在中国科学院大学中国科学院微生物研究所获理学博士学位。2016–2020年在中国科学院北京生命科学研究院比较与进化免疫学课题组任助理研究员,2021年晋升为副研究员。长期从事重要病原的入侵与致病机制研究。在基孔肯雅病毒和γ疱疹病毒入侵机制,H7N9H4N6D型流感病毒跨种传播、以及寨卡病毒、新冠病毒致病机制及防治新靶点发现等研究方面取得了一系列成果,在CellScienceNature Structural & Molecular BiologyEMBO JournalPLoS Pathogens等国际SCI期刊发表40余篇研究论文。研究成果曾被选为F1000 prime推荐,入选2019年度中国医学重大进展(基础医学部)。参编著作4部,主译《时不我待》等科普书籍。主持国家自然科学基金面上项目等。入选中国科协“青年人才托举工程”。 

研究领域:

  重要病原的入侵与致病机制以及防治新靶点发现。 

代表论著:
  1. Modhiran N#, Song H#, Liu L, Bletchly C, Brillault L, Amarilla AA, Xu X, Qi J, Chai Y, Cheung STM, Traves R, Setoh YX, Bibby S, Scott CAP, Freney ME, Newton ND, Khromykh AA, Chappell KJ, Muller DA, Stacey KJ, Landsberg MJ, Shi Y*, Gao GF*, Young PR*, Watterson D*. A broadly protective antibody that targets the flavivirus NS1 protein. Science, 2021, 371(6525): 190-194
  2. Xie Y#, Li X#, Chai Y, Song H*, Qi J*, Gao GF*. Structural basis of malarial parasite RIFIN-mediated immune escape against LAIR1. Cell Reports, 2021, 36: 109600.
  3. Su C#, Wu L#, Chai Y, Qi J, Tan S, Gao GF*, Song H*, Yan J*. Molecular basis of EphA2 recognition by gHgL from gammaherpesviruses. Nature Communications, 2020, 11(1):5964
  4. Peng Y, Du N, Lei Y, Dorje S, Qi J, Luo T, Gao GF*, Song H*. Structures of the SARS-CoV-2 nucleocapsid and their perspectives for drug design. EMBO Journal, 2020, 39(20):e105938
  5. Zhao R#, Li M#, Song H#, Chen J, Ren W, Feng Y, Gao GF, Song J, Peng Y, Su B, Guo X, Wang Y, Chen J, Li J, Sun H, Bai Z, Cao W, Zhu J, Zhang Q, Sun Y, Sun S, Mao X, Su J, Chen X, He A, Gao W, Jin R*, Jiang Y*, Sun L*. Early Detection of Severe Acute Respiratory Syndrome Coronavirus 2 antibodies as a serologic marker of infection in patients with coronavirus disease 2019. Clinical Infectious Diseases, 2020, 71(16): 2066-2072
  6. Song H#, Zhao ZN#, Chai Y#, Jin X, Li C, Yuan F, Liu S, Gao Z, Wang H, Song J, Vazquez L, Zhang Y, Tan S, Morel C, Yan J, Shi Y, Qi J, Gao F*, Gao GF*. Molecular basis of arthritogenic alphavirus receptor MXRA8 binding to Chikungunya virus envelope protein. Cell, 2019, 177, 1-11
  7. Wang Q#*, Song H#, Cheng H, Qi J, Nam G, Tan S, Wang J, Fang M, Shi Y, Tian Z, Cao X, An Z, Yan J, Gao GF*. Structures of the four Ig-like domain LILRB2 and the four-domain LILRB1 and HLA-G1 complex. Cell Mol Immunol, 2020, 17(9): 966-975
  8. Shang Z#, Song H#, Shi Y, Qi J*, Gao GF*. Crystal Structure of the Capsid Protein from Zika Virus. Journal of Molecular Biology, 2018, 430: 948-962.
  9. Wang H, Han M, Qi J, Hilgenfeld R, Luo T, Shi Y, Gao GF*, Song H*. Crystal structure of the C-terminal fragment of NS1 protein from yellow fever virus. Science China Life Sciences, 2017, 60(12): 1403-1406
  10. Song H, Qi J, Xiao H, Bi Y, Zhang W, Xu Y, Wang F, Shi Y, Gao GF*. Avian-to-human receptor-binding adaptation by influenza A virus hemagglutinin H4. Cell Reports, 2017, 20(5): 1201-1214
  11. Duan W#, Song H#, Wang H, Chai Y, Su C, Qi J, Shi Y*, Gao GF*. The crystal structure of Zika virus NS5 reveals conserved drug targets. EMBO Journal, 2017, 36(7): 919-933
  12. Xu X#, Song H#, Qi J, Liu Y, Wang H, Su C, Shi Y*, Gao GF*. Contribution of intertwined loop to membrane association revealed by Zika virus full-length NS1 structure. EMBO Journal, 2016, 35(20):2170-8
  13. Song H, Qi J, Haywood J, Shi Y, Gao GF. Zika virus NS1 structure reveals diversity of electrostatic surfaces among flaviviruses. Nature Structural & Molecular Biology, 2016, 23: 456-458
  14. Song H, Qi J, Khedri Z, Diaz S, Yu H, Chen X, Varki A, Shi Y, Gao GF*.An Open Receptor-Binding Cavity of Hemagglutinin-Esterase-Fusion Glycoprotein from Newly-Identified Influenza D Virus: Basis for Its Broad Cell Tropism. PLoS Pathogens, 2016, 12(1):e1005411