研究队伍
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姓  名:
孙中生
学  科:
基因组学及行为遗传学
联系电话:
010-64864959
电子邮件:
sunzs@biols.ac.cn
通讯地址:
北京市朝阳区北辰西路1号院5号 100101
更多信息:
  
简历:
    博士,研究员,博士生导师,中国遗传学会表观遗传专业委员会主任, Hormones and Behavior杂志编委。1982年北京大学学士;1992年美国德克萨斯A&M大学博士;1993-1998年先后在德克萨斯大学安德生癌症研究中心放射治疗系、贝勒医学院分子人类遗传学系做博士后;1998-1999年任路易斯安那州立大学神经科学中心助理教授、主任助理,同时任生物化学和遗传系助理教授;1999-2005年在美国康奈尔大学任助理教授,威尔医学院特护医学实验室主任;2005-2010年在中国科学院心理研究所行为遗传学中心任研究员,2010年至今任北京生科院研究员。1997年,荣获Science杂志十大科学突破,2006年入选中科院“百人计划”,并入选“新世纪百千万人才工程”。
研究领域:

    基因组学、表观基因组学、行为遗传学 
    1.疾病及生命现象的基因组及表观基因组研究。本研究的长期目标是利用基因组学手段揭示控制生物学表型的遗传及表观遗传代码。首先发展全基因组水平的表观遗传密码的分析技术,包括基于新一代测序仪的全基因组DNA甲基化谱图的分析方法及组蛋白修饰分析方法。随后,利用此项技术在全基因组上分析复杂生物现象、疾病与DNA甲基化及组蛋白修饰的关系。此外,还将开发基于新一代测序仪的全外显子组测序技术,并利用此技术在全基因组水平上分析孤独症等复杂疾病与基因突变的关系。 
    2.疾病及生命现象的生物钟调控机制研究。在基因组、细胞及行为学水平上分析免疫与生物钟、心血管疾病与生物钟、药物成瘾与生物钟、疼痛与时间生物学的关系,了解受节律基因控制的相关生理过程的生物钟调控机制。此外,我们认为生理节律除了受生物钟基因的调控,还与组蛋白构型的24小时节律相关,因此,我们试图揭示二者之间的关系。 
    3.表观基因组分析算法及工具的开发。人类基因组中大部分的DNA甲基化发生在重复序列(repetitive genomic sequences)区,这些区域的DNA甲基化在维持基因组稳定性过程中发挥着至关重要的作用,并可能影响了恶性肿瘤的发生发展。但是目前单碱基分辨率的DNA甲基化分析方法所产生的短序列在重复序列区的比对、定位上存在重大缺陷,我们拟在前期已成功开发甲基化可视化软件iMethy的基础上,进一步开发重复序列区DNA甲基化的分析算法和工具,提高甲基化修饰碱基的辨识率,为肿瘤基因组稳定性研究提供技术支撑。

代表论著:
  1. Liang J#, Feng D#, Cai W#, Teng H, Mao F, Jiang Y, Hu S, Li X, Zhang Y, Liu B*, Sun Z*. Genetic landscape of papillary thyroid carcinoma in the Chinese population: Somatic mutational profile of PTC in China. Journal of Pathology. 2017, doi: 10.1002/path.5005.
  2. Mao F#, Liu Q#, Zhao X#, Yang H, Guo S, Xiao L, Li X, Teng H*, Sun Z*, Dou Y*. EpiDenovo: a platform for linking regulatory de novo mutations to developmental epigenetics and diseases. Nucleic Acids Res. 2017 Oct 10. doi: 10.1093/nar/gkx918.
  3. Li J#, Shi L#, Zhang K, Zhang Y, Hu S, Zhao T, Teng H, Li X, Jiang Y, Ji L*, Sun Z*. VarCards: an integrated genetic and clinical database for coding variants in the human genome. Nucleic Acids Res. 2017 Nov 3. doi: 10.1093/nar/gkx1039
  4. Li X, Shi L, Zhang K, Wei W, Liu Q, Mao F, Li J, Cai W, Chen H, Teng H*, Li J*, Sun Z*. CirGRDB: a database for the genome-wide deciphering circadian genes and regulators. Nucleic Acids Res. 2017 Oct 20. doi: 10.1093/nar/gkx944.
  5. Li J#, Wang L#, Guo H, Shi L, Zhang K, Tang M, Hu S, Dong S, Liu Y, Wang T, Yu P, He X, Hu Z, Zhao J, Liu C*, Sun ZS*, Xia K*. Targeted sequencing and functional analysis reveal brain-size-related genes and their networks in autism spectrum disorders. Mol Psychiatry. 2017,22(9):1282-1290.
  6. Teng H#, Zhang Y#, Shi C#, Mao F, Cai W, Lu L, Zhao F*, Sun Z*, Zhang J*. Population Genomics Reveals Speciation and Introgression between Brown Norway Rats and Their Sibling Species. Mol Biol Evol. 2017,34(9):2214-2228.
  7. Zhong JN, Li XF, Cai WS, Wang Y, Dong SS, Yang J, Zhang J, Wu NN, Li YY, Mao FB, Zeng C, Wu JY, Xu NZ, Sun ZS*. TET1 modulates H4K16 acetylation by controlling auto-acetylation of hMOF to affect gene regulation and DNA repair function. Nucleic Acids Res. 2017,45(2):672-684
  8. Wang Y, Liu H, Sun Z*. Lamarck rises from his grave: parental environment-induced epigenetic inheritance in model organisms and humans. Biol Rev Camb Philos Soc. 2017,92(4):2084-2111
  9. Wang J, Zhang K, Chen X, Liu X, Teng H, Zhao M*, Sun Z*. Epigenetic Activation of ASCT2 in the Hippocampus Contributes to Depression-Like Behavior by Regulating D-Serine in Mice. Front Mol Neurosci. 2017,10:139. doi: 10.3389/fnmol.2017.00139.eCollection
  10. Miao Z, Mao F, Liang J, Szyf M, Wang Y*, Sun ZS*. Anxiety-Related Behaviours Associated with microRNA-206-3p and BDNF Expression in Pregnant Female Mice Following Psychological Social Stress. Mol Neurobiol. 2017 Jan 14. doi: 10.1007/s12035-016-0378-1.
  11. Li J#, Cai T#, Jiang Y, Chen H, He X, Chen C, Li X, Shao Q, Ran X, Li Z, Xia K, Liu C*, Sun ZS*, Wu J*. Genes with de novo mutations are shared by four neuropsychiatric disorders discovered from NPdenovo database. Mol Psychiatry. 2016,21(2): 290–297
  12. Mao F, Xiao L, Li X, Liang J, Teng H, Cai W*, Sun ZS*. RBP-Var: a database of functional variants involved in regulation mediated by RNA-binding proteins. Nucleic Acids Res. 2016,44(D1):D154-63
  13. Yu P, Yang W, Han D, Wang X, Guo S, Li J, Li F, Zhang X, Wong SW, Bai B, Liu Y, Du J, Sun ZS, Shi S, Feng H, Cai T*. Mutations in WNT10B Are Identified in Individuals with Oligodontia. Am J Hum Genet. 2016 Jul 7;99(1):195-201.
  14. Chen S, Li M, Zhu W, Mao F, Wang J, Sun Z*, Huang X*. A novel 10-base pair insertion mutation in exon 5 of the SOD1 gene in a Chinese family with amyotrophic lateral sclerosis. Neurobiol Aging. 2016 Sep;45:212.e1-4.
  15. Cai W#, Mao F#, Teng H, Cai T, Zhao F, Wu J*, Sun ZS*. MBRidge: an accurate and cost-effective method for profiling DNA methylome at single-base resolution. Journal of Molecular Cell Biology. 2015,7(4):299-313. doi: 10.1093/jmcb/mjv037
  16. Wang JS#, Luo YL#, Wang KL, Wang Y, Zhang XL, Teng HJ*, Sun ZS*. Clock-controlled StAR's expression and corticosterone production contribute to the endotoxemia immune response. Chronobiology International. 2015, 32: 358-367
  17. Wang K#, Li X#, Dong S, Liang J, Mao F, Zeng C, Wu H, Wu J, Cai W*, Sun ZS*. Q-RRBS: a quantitative reduced representation bisulfite sequencing method for single-cell methylome analyses. Epigenetics. 2015 Sep 2;10(9):775-83.
  18. Cai T, Yang L, Cai W, Guo S, Yu P, Li J, Hu X, Yan M, Shao Q, Jin Y, Sun ZS, Luo ZJ*. Dysplastic spondylolysis is caused by mutations in the diastrophic dysplasia sulfate transporter gene. Proc. Natl. Acad. Sci. U.S.A. 2015 Jun 30;112(26):8064-9.
  19. Wang G, Li X, Tian W, Wang Y, Wu D, Sun Z*, Zhao E*. Promoter DNA methylation is associated with KLF11 expression in epithelial ovarian cancer. Genes Chromosomes Cancer. 2015,54(7):453-62.
  20. Nemoda Z, Massart R, Suderman M, Hallett M, Li T, Coote M, Cody N, Sun ZS, Soares CN, Turecki G, Steiner M7, Szyf M*. Maternal depression is associated with DNA methylation changes in cord blood T lymphocytes and adult hippocampi. Transl Psychiatry. 2015 Apr 7;5:e545. doi: 10.1038/tp.2015.32.
  21. Li Z#, Wang Y#, Sun KK, Wang K, Sun ZS*, Zhao M*, Wang J*. Sex-related difference in food-anticipatory activity of mice. Horm Behav. 2015 Feb 28;70:38-46.
  22. Yu P, Cui Y, Cai W, Wu H, Xiao X, Shao Q, Ma L, Guo S, Wu N, Jin ZB, Wang Y, Cai T, Sun ZS, Qu J*. Lysosomal storage disease in the brain: mutations of the β-mannosidase gene identified in autosomal dominant nystagmus. Genet Med. 2015,17(12):971-9
  23. Li J, Jiang Y, Wang T, Chen H, Xie Q, Shao Q, Ran X, Xia K, Sun ZS*, Wu J*. mirTrios: an integrated pipeline for detection of de novo and rare inherited mutations from trios-based next-generation sequencing. J Med Genet. 2015,52(4):275-81
  24. Wu C, Qiu S, Lu L, Zou J, Li WF, Wang O, Zhao H, Wang H, Tang J, Chen L, Xu T, Sun Z, Liao W, Luo G, Lu X*. RSPO2–LGR5 signaling has tumour-suppressive activity in colorectal cancer. Nat Commun. 2014;5:3149. doi: 10.1038/ncomms4149
  25. Ran X, Li J, Shao Q, Chen H, Lin Z, Sun ZS*, Wu J*. EpilepsyGene a genetic resource for genes and mutations related to epilepsy. Nucleic Acids Res. 2014,43(Database issue):D893-9
  26. Wang Y, Li GL, Mao FB, Li XF, Liu Q, Chen L, Lv L, Wang X, Wu JY, Dai W, Wang G, Zhao EF , Tang KF*, Sun ZS*. Ras-induced Epigenetic Inactivation of the RRAD (Ras-related Associated with Diabetes) Gene Promotes Glucose Uptake in a Human Ovarian Cancer Model. J. Biol. Chem. 2014, 289:14225-14238.
  27. Xie Q, Liu Q, Mao F, Cai W, Wu H, You M, Wang Z, Chen B, Sun ZS*, Wu J*. A Bayesian framework to identify methylcytosines from high-throughput bisulfite sequencing data. PLoS Comput Biol. 2014 Sep 25;10(9):e1003853.
  28. Wang Y#, Wang Y#, Liu Q, Xu G, Mao F, Qin T, Teng H, Cai W, Yu P, Cai T, Zhao M*, Sun ZS*, Xie C*. Comparative RNA-seq analysis reveals potential mechanisms mediating the conversion to androgen independence in an LNCaP progression cell model. Cancer Lett. 2014,342(1):130-8.
  29. Wang Z#, Cai W#, Cui F, Cai T, Chen Z, Mao F, Teng H, Chen L, Wang J, Sun Z*, Huang X*, Yu P*. Identification of a novel missense (C7W) mutation of SOD1 in a large familial amyotrophic lateral sclerosis pedigree. Neurobiol Aging. 2014,35(3):725.e11-5.
  30. Wang T, Liu Q, Li X, Wang X, Li J, Zhu X, Sun ZS*, Wu J*.RRBS-Analyser: A Comprehensive Web Server for Reduced Representation Bisulfite Sequencing Data Analysis. Hum Mutat. 2013 Dec;34(12):1606-10.
  31. Bi C, Wu J, Jiang T, Liu Q, Cai W, Yu P, Cai T, Zhao M, Jiang YH, Sun ZS*. Mutations of ANK3 identified by exome sequencing are associated with autism susceptibility. Human Mutation. 2012 Aug 3. doi: 10.1002/humu.22174. 
  32. Wu JY, Shen EJ, Shi DS, Sun ZS* and Cai T*. Identification of a novel Cys146X mutation of SOD1 in familial amyotrophic lateral sclerosis by whole-exome sequencing. Genetics in Medicine. 2012 May 17. doi: 10.1038/gim.2012.50. 
  33. Zhang J, Li H, Teng H, Zhang T, Luo Y, Zhao M, Li YQ, Sun ZS*. Regulation of Peripheral Clock to the Oscillation of Substance P Contributes to Circadian Inflammatory Pain. Anesthesiology. 2012 Jul;117(1):149-160 
  34. Hou HB, Zhao FQ, Zhou LL, Zhu EL, Teng HJ, Li XK, Bao QY, Wu JY, Sun ZS*. MagicViewer: integrated solution for next-generation sequencing data visualization and genetic variation detection and annotation. Nucleic Acids Res. 2010 May 5. doi:10.1093/nar/gkq302 
  35. Zhu EL, Zhao FQ, Xu G, Hou HB, Zhou LL, Yang HM, Li XK, Sun ZS*, Wu JY*. mirTools: microRNA profiling and discovery based on high-throughput sequencing. Nucleic Acids Res. 2010, doi:10.1093/nar/gkq393 
  36. Boivin D, James F, Wu, A., Park, C., Xiong H., Sun ZS*. Circadian Clock Genes oscillate in human peripheral blood mononuclear cell. Blood, 2003, 102 (12):  4143-4146.  
  37. Zheng B, Albrecht U, Sage M, Vaishnav S, Sun ZS, Eichele G, Bradley A, Lee CC. Nonredundant roles of the mPer1 and mPer2 genes in the mammalian circadian clock. Cell, 2001, 105, 683-694. 
  38. Zheng B, Larkin DW, Albrecht U, Sun ZS, Sage M, Eichele G, Lee CC, Bradley A. The mPer2 gene encodes a functional component of the mammalian circadian clock. Nature 1999, 400, 169-173. 
  39. Albrecht U, Sun ZS, Eichele G, Lee CC. A differential response of two putative mammalian circadian regulators, mper1 and mper2, to light. Cell, 1997, 91 (7) 1055-1064.  
  40. Sun ZS, Albrecht U, Zhuchenko O, Bailey J, Eichele G, Lee CC. Rigui, a putatuive mammalian ortholog of the drosophila period gene. Cell 1997, 90 (6), 1003-1011. 
研究组成员:


工作人员
王  彦 博士 副研究员
滕花景 博士 助理研究员

研究生
梁加龙 博士生 2015年 梅  月 硕士生 2014年
曾  程 博士生 2016年 张江红 硕士生 2014年
李媛媛 博士生 2017年 韦文青 硕士生 2016年 
                     李青兰 硕士生 2017年
                  

李先锋* 李津臣* 王琳* 吴豪达* 石晓辉* 陈云* 汪星星* 史雷胜* 张坤* 赵婷婷* 李娜* 张燚*  (*为联合培养研究生)